Anti Microbial, Anti Oxidant and Anticancer Activity of La/Bi/Cu Trimetal/Chitosan Nanocomposites

Abstract

Chitosan has been reported to be an effective chelating or fixing agent due the number of NH2 and OH groups, high adhesion and mechanical strength. It has wide potential applications,especially in drug delivery. In the present study, we report the facile synthesis of La/Bi/Cu /chitosan nanocomposites and their physical properties. La/Bi/Cu trimetal nanoparticles were synthesized by chemical reduction of corresponding metal salts with NaBH4 in the presence of chitosan, when chitosan molecules adsorb on to the surface of as-prepared La/Bi/Cu trimetal nanoparticles forming La/Bi/Cu /Chitosan nanocomposites. Natural chitosan not only acts as supporting matrix, but also serves as a stabilizer for the formation ofLa/Bi/Cu trimetal nanoparticles. La/Bi/Cu /Chitosan nanocomposites have better antioxidant activity.La/Bi/Cu /Chitosan nanocomposites acts as better antimicrobial activity against bacteria and fungus. La/Bi/Cu /Chitosan nanocomposites have cytotoxic activity against HOS cell line. The optical properties, morphologies, structure, chemical compositions and electronic properties of La/Bi/Cu /chitosan composites were  characterized by XRD, FTIR, SEM and UV–visible absorption spectroscopy. The SEM images showed variation in morphology of the particles. The XRD pattern revealed the crystalline nature of the nanocomposites.